Vaas Montenegro (Far Cry 3)
Vaas’s legacy comes from his unmatched unpredictability. One moment he can be friendly and funny, and the next he can be the cruelest and most sadistic individual you’ve ever noticed. You truly don’t know what you’re going to get from Vaas.
The Illusive Man (Mass Effect series)
Like the Prophet of Truth, the Illusive Man was a person that succeeded in the art of manipulation and subterfuge. The mysterious Cerberus leader was able to build up an extensive and advanced military power in a galaxy full of arms restrictions because of this quality.
The Covenant (Halo series)
While not as powerful as the Combine or the Reapers, the Covenant have an exceptional motivation for their conquest: obtaining religious salvation.
Kreia (Star Wars Knights of the Old Republic II: The Sith Lords)
Kreia is such an interesting person because of the way that she gives a remarkable philosophical perspective on the Force: both the Jedi and the Sith are off-base in the ways that they use it.
Handsome Jack (Borderlands series)
Through his insults and abusive tendencies, he’s a person who truly appears to be the world’s biggest douche. However, the way that he’s so funny and witty makes you love him same time. More than some other antagonist on this list, you hate to love him, and love to hate him.